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Show off your elegant taste when you put on this sleek piece of 925 Sterling Silver Natural Larimar Hexagon Pendant Necklace around your dainty neck. Larimar’s beautiful blue color is often considered to embody the beautiful blue colors of the sea and sky found in the Caribbean. Its origin and appearance have made it popularly known as the Caribbean Gem. Larimar is considered a healing stone, and said to be finely tuned to the human body. It supports the body’s natural healing process. Larimar is also called the Atlantis Stone, because a Spiritual master claimed that some islands in the Caribbean were part of the lost continent of Atlantis. He went further to say that on one of those islands a blue stone with healing powers would be found. As the hexagon is found throughout nature, organized religions insist it is a symbol of harmony and balance. However, the esoteric wisdom of the hexagon goes much deeper – right to the heart of our origins. Of all the geometric shapes in sacred geometry, the hexagon is arguably the most powerful and fascinating. This necklace is high polished and is rhodium plated to protect the jewelry from tarnishing and provided with 18 inches chain for your maximum comfort and security while wearing it. A classy jewelry that will give enough sophistication to anyone who possess it.
Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.16
Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.
High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.
Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.
Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs;